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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-VHL-IN-15
VHL-IN-15

Chemical Structure : VHL-IN-15

CAS No.: 1360616-29-0

VHL-IN-15

货号: PC-62451Not For Human Use, Lab Use Only.

VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction..

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.

物理化学性质&存储条件

分子量 410.43
分子式 C21H22N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide

参考文献

1. Buckley DL, et al. J Am Chem Soc. 2012 Mar 14;134(10):4465-8.

2. Van Molle I, et al. Chem Biol. 2012 Oct 26;19(10):1300-12.

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