VGTI-A3-03 |CAS: 2772833-19-7 Probechem Biochemicals

Chemical Structure : VGTI-A3-03

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VGTI-A3-03

货号: PC-35007Not For Human Use, Lab Use Only.

VGTI-A3-03 is a potent, highly virus-specific inhibitor of DENV replication with greatest activity against DENV serotype 2 (IC50=25 nM), directly binds DENV capsid protein.

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生物&药学活性

VGTI-A3-03 is a potent, highly virus-specific inhibitor of DENV replication with greatest activity against DENV serotype 2 (IC50=25 nM), directly binds DENV capsid protein.
VGTI-A3-03 also demonstrates some inhibitory activity against DENV1, DENV4, and WNV.
VGTI-A3-03 does not inhibit viral RNA replication or secretion of viral particles, significantly diminishe secreted particles in treated cells, the binding pocket in the capsid molecule is at the dimerization interface.
VGTI-A3-03 is incorporated into virus particles released from infected cells.

物理化学性质&存储条件

分子量	483.608
分子式	C26H21N5OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-6-phenyl-N-(4-phenylthiazol-2-yl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

参考文献

1. Smith JL, et al. Antiviral Res. 2018 Apr 27;155:12-19.

VGTI-A3-03

生物&药学活性

物理化学性质&存储条件

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VGTI-A3-03

生物&药学活性

物理化学性质&存储条件

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