VG081821 | A2A receptor antagonist | Probechem Biochemicals

Chemical Structure : VG081821

加入收藏

VG081821 (VG-081821)

货号: PC-25168Not For Human Use, Lab Use Only.

VG081821 is a potent, selective, orally active A2A adenosine receptor antagonist with binding Ki of 0.85 nM, >300-fold selective over A1, A2B, and A3 receptors.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

VG081821 is a potent, selective, orally active A2A adenosine receptor antagonist with binding Ki of 0.85 nM, >300-fold selective over A1, A2B, and A3 receptors.
VG081821 down-regulates intracellular cAMP levels by the cAMP TR-FRET assay with IC50 of 5.77 nM.
VG081821 is simultaneously a highly potent antagonist and inverse agonist of A2A receptor, has the inverse agonistic EC50 values of 0.74 nM.
VG081821 exhibits lower intrinsic clearance and superior pharmacokinetic profile compared to ZM241385.

物理化学性质&存储条件

分子量	392.42
分子式	C19H20N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(furan-2-yl)-N5-(4-(oxetan-3-ylamino)phenethyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine

参考文献

1. Sun S, et al. Drug Dev Res. 2025 Aug;86(5):e70133.

VG081821 (VG-081821)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

VG081821 (VG-081821)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.