VG-3927 | TREM2 agonist | Probechem Biochemicals

Chemical Structure : VG-3927

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VG-3927 (Compiund I-192)

货号: PC-24792Not For Human Use, Lab Use Only.

VG-3927 (I-192) is a highly potent, selective and brain penetrant triggering receptor expressed on myeloid cells 2 (TREM2) agonist.

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生物&药学活性

VG-3927 (I-192) is a highly potent, selective and brain penetrant triggering receptor expressed on myeloid cells 2 (TREM2) agonist.
VG-3927 promotes TREM2 clustering rather than acting as a direct ligand
VG-3927 promoted anti-inflammatory microglia activation and suppressed a broad spectrum of neurodegeneration-associated biomarkers. reduced pathological forms of Aβ, insoluble ApoE levels, and peri-plaque dystrophic neurites after 6 weeks of oral dosing in humanized TREM2 plaque-bearing mice.
VG-3927 shows favorably tune human microglia activation and impart a broadly neuroprotective profile across preclinical model systems.

物理化学性质&存储条件

分子量	451.93
分子式	C24H23ClFN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-chloro-2-fluorophenyl)-2,3-dimethyl-7-((2R,4S)-2-(1-methyl-1H-pyrazol-4-yl)tetrahydro-2H-pyran-4-yl)pyrido[3,4-b]pyrazine

参考文献

1. Christian Mirescu, et al. Alzheimers Dement. 2025, 20(Suppl 6), e089318.

2. Hossam Nada, et al. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.

VG-3927 (Compiund I-192)

生物&药学活性

物理化学性质&存储条件

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VG-3927 (Compiund I-192)

生物&药学活性

物理化学性质&存储条件

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