VERU-111 (Sabizabulin, ABI-231) | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : VERU-111

CAS No.: 1332881-26-1

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VERU-111 (Sabizabulin, VERU111, ABI-231)

货号: PC-35597Not For Human Use, Lab Use Only.

VERU-111 (Sabizabulin, VERU111) is an oral cytoskeleton disruptor that targets and inhibits microtubules to disrupt androgen receptor transport into the nucleus, shows broad antiviral activity by disrupting the intracellular transport of viruses such as SARS CoV-2.

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10 mg	￥4580	In stock
25 mg	￥7980	In stock
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生物&药学活性

VERU-111 (Sabizabulin, ABI-231) is an oral cytoskeleton disruptor that targets and inhibits microtubules to disrupt androgen receptor transport into the nucleus, shows broad antiviral activity by disrupting the intracellular transport of viruses such as SARS CoV-2.
VERU-111 (Sabizabulin, VERU111) inhibits cell viability of human melanoma cell lines (A375, M14, and RPMI7951) with IC50 of 5-10 nM.
Sabizabulin was tested in a Phase 1b/2 clinical study in men with metastatic castration resistant prostate cancer (mCRPC), as well as COVID-19 infection.

物理化学性质&存储条件

分子量	377.4
分子式	C21H19N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

参考文献

1. Wang Q, et al. J Med Chem. 2018 Aug 30. doi: 10.1021/acs.jmedchem.8b00827.
2. Mark C Markowski, et al. Clin Cancer Res. 2022 Apr 13;clincanres.0162.2022.

VERU-111 (Sabizabulin, VERU111, ABI-231)

生物&药学活性

物理化学性质&存储条件

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VERU-111 (Sabizabulin, VERU111, ABI-231)

生物&药学活性

物理化学性质&存储条件

参考文献

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