VE607 | SARS-CoV entry inhibitor | Probechem Biochemicals

Chemical Structure : VE607

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VE607 (VE-607)

货号: PC-38897Not For Human Use, Lab Use Only.

VE607 is a specific small molecule inhibitor that block S protein-ACE2-mediated cellular entry of the SARS-CoV, inhibits pseudovirus entry with EC50 of 3 μM and inhibited SARS-CoV plaque formation with EC50 of 1.6 μM.

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生物&药学活性

VE607 is a specific small molecule inhibitor that block S protein-ACE2-mediated cellular entry of SARS-CoV, inhibits pseudovirus entry with EC50 of 3 μM and inhibited SARS-CoV plaque formation with EC50 of 1.6 μM.
VE607 does not protect Vero cells from poliovirus plaque formation.
VE607 broadly inhibits pseudoviral particles bearing the Spike from major VOCs (D614G, Alpha, Beta, Gamma, Delta, Omicron - BA.1 and BA.2) as well as authentic SARS-CoV-2 at low micromolar concentrations.
VE607 binds to the receptor binding domain (RBD)-ACE2 interface and stabilizes RBD in its "up" conformation.

物理化学性质&存储条件

分子量	392.540
分子式	C22H36N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[3-(2-Hydroxyl-3-piperidin-1-yl-propoxy)-phenoxy]-3-piperidin-1-ylpropan-2-ol

参考文献

1. Kao RY, et al. Chem Biol. 2004 Sep;11(9):1293-9.

2. Ding S, et al. bioRxiv. 2022 Feb 22:2022.02.03.479007..

VE607 (VE-607)

生物&药学活性

物理化学性质&存储条件

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VE607 (VE-607)

生物&药学活性

物理化学性质&存储条件

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