VDX-111 | | Probechem Biochemicals

Chemical Structure : VDX-111

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VDX-111 (AMPI-109, VDX111)

货号: PC-22100Not For Human Use, Lab Use Only.

VDX-111 (AMPI-109) is a selectively active agent against TNBC cell lines, inhibits proliferation and induces apoptosis of multiple TNBC subtype cell lines with IC50 of 100 nM.

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生物&药学活性

VDX-111 (AMPI-109) is a selectively active agent against TNBC cell lines, inhibits proliferation and induces apoptosis of multiple TNBC subtype cell lines with IC50 of 100 nM.
VDX-111 (AMPI-109) also inhibits the growth of a panel of ovarian cancer cell lines, focusing on BRCA wild-type lines.
VDX-111 (AMPI-109) causes a dose-dependent loss of cell viability across ovarian cancer cell lines.
VDX-111 (AMPI-109) inhibits tumor growth in patient-derived xenograft and syngeneic murine models.

物理化学性质&存储条件

分子量	537.57
分子式	C29H45BrO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3S,5Z)-3-Hydroxy-4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]

参考文献

1. Hamid H Gari, et al. Oncotarget. 2016 Mar 29;7(13):15757-71.

VDX-111 (AMPI-109, VDX111)

生物&药学活性

物理化学性质&存储条件

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VDX-111 (AMPI-109, VDX111)

生物&药学活性

物理化学性质&存储条件

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