VDR 4-1 |CAS:303203-28-3 Probechem Biochemicals

Chemical Structure : VDR 4-1

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VDR 4-1

货号: PC-61773Not For Human Use, Lab Use Only.

VDR 4-1 is a novel non-steroidal, small-molecule agonist of vitamin D receptor (VDR).

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生物&药学活性

VDR 4-1 is a novel non-steroidal, small-molecule agonist of vitamin D receptor (VDR); demonstrates potent transcriptional activities in a VDR reporter gene assay, and significantly ameliorates cardiac hypertrophy in cell culture and in animal models; also effectively suppresses secondary hyperparathyroidism in 1α-hydroxylase knockout mice; does not induce hypercalcemia at high doses in contrast to naturally occurring VDR agonist (1,25-D3 or calcitriol).

物理化学性质&存储条件

分子量	512.061
分子式	C28H30ClNO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(ethylthio)ethyl 7-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

参考文献

1. Khedkar SA, et al. Sci Rep. 2017 Aug 16;7(1):8427.

VDR 4-1

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VDR 4-1

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