VCP Activator 1 | VCP/p97 activator | Probechem Biochemicals

Chemical Structure : VCP Activator 1

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VCP Activator 1 (VA1, VCP ATPase Activator 1, VAA1)

货号: PC-21286Not For Human Use, Lab Use Only.

VCP Activator 1 (VA1) is a small molecule allosteric activator of valosin-containing protein (VCP)/p97, dose-dependently stimulates VCP ATPase activity up to 3-fold (EC50= 4 uM).

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生物&药学活性

VCP Activator 1 (VA1) is a small molecule allosteric activator of valosin-containing protein (VCP)/p97, dose-dependently stimulates VCP ATPase activity up to 3-fold (EC50= 4 uM).
VCP Activator 1 (VA1) binds in an allosteric pocket near the VCP D2 ATP-binding site in both the apo and ADP-bound states.
VCP Activator 1 (VA1) direct interactions with VCP with ITC KD of 27 uM.

物理化学性质&存储条件

分子量	354.47
分子式	C20H22N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(2-(ethylthio)phenyl)-3-(1-oxoisoindolin-2-yl)butanamide

参考文献

1. N H Jones, et al. bioRxiv. 2023 Oct 2:2023.10.02.560478.

VCP Activator 1 (VA1, VCP ATPase Activator 1, VAA1)

生物&药学活性

物理化学性质&存储条件

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VCP Activator 1 (VA1, VCP ATPase Activator 1, VAA1)

生物&药学活性

物理化学性质&存储条件

参考文献

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