VBIT-12 | VDAC1 inhibitor | Probechem Biochemicals

Chemical Structure : VBIT-12

CAS No.: 2089227-65-4

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VBIT-12 (VDAC1 inhibitor)

货号: PC-38802Not For Human Use, Lab Use Only.

VBIT-12 is a selective inhibitor of the mitochondria gate-keeper protein, voltage-dependent-anion channel 1 (VDAC1), directly interacting with purified VDAC1 and reducing the channel conductance.

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10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

VBIT-12 is a selective inhibitor of the mitochondria gate-keeper protein, voltage-dependent-anion channel 1 (VDAC1), directly interacting with purified VDAC1 and reducing the channel conductance.
VBIT-12 treatment of cultured colon cells inhibited the DSS-induced VDAC1 overexpression, oligomerization, and apoptosis.
VBIT-12 suppressed weight loss, diarrhea, rectal bleeding, pro-inflammatory cytokine production, crypt and epithelial cell damage, and focal inflammation in DSS-treated mice

物理化学性质&存储条件

分子量	417.509
分子式	C25H27N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1-(naphthalen-1-ylmethyl)-4-(phenylamino)piperidine-4-carbonyl)glycine

参考文献

1. Verma A, et al. Mol Ther. 2022 Feb 2;30(2):726-744.

2. Niu B, et al. Cell Biol Toxicol. 2021 Aug 17. doi: 10.1007/s10565-021-09624-x.

VBIT-12 (VDAC1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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VBIT-12 (VDAC1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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