VB124 | MCT4 inhibitor | Probechem Biochemicals

Chemical Structure : VB124

CAS No.: 2230186-18-0

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VB124 (VB-124)

货号: PC-38048Not For Human Use, Lab Use Only.

VB124 is a selective, highly potent MCT4 inhibitor, blocks lactate import (IC50 =8.6 nM) and export (IC50=19 nM) in MDA-MB-231 cells.

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5 mg	￥2280	In stock
10 mg	￥3680	In stock
25 mg	￥5580	In stock
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生物&药学活性

VB124 is a selective, highly potent MCT4 inhibitor, blocks lactate import (IC50 =8.6 nM) and export (IC50=19 nM) in MDA-MB-231 cells.
VB124 is highly selective for MCT4 over MCT1, showing very little MCT1 inhibitory activity (IC50=24 μM) in MCT1-expressing BT20 cells.
VB124 prevents and reverses hypertrophy in cardiomyocytes, prevents the increased flux from glucose into pyruvate and intra- and extracellular lactate observed in PE- and ISO-treated cardiomyocytes.
VB124 replenishes mitochondrial pyruvate flux, improves mitochondrial membrane potential and mitigates cytosolic ROS.
VB124 prevents cardiac hypertrophy in mice.

物理化学性质&存储条件

分子量	426.89
分子式	C23H23ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1-(2-chlorophenyl)-5-(3-cyclopropoxyphenyl)-1H-pyrazol-3-yl)methoxy)-2-methylpropanoic acid

参考文献

1. Cluntun AA, et al. Cell Metab. 2021 Mar 2;33(3):629-648.e10.

2. Fang Y, et al. Hepatology. 2022 Jan 19.

VB124 (VB-124)

生物&药学活性

物理化学性质&存储条件

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VB124 (VB-124)

生物&药学活性

物理化学性质&存储条件

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