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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Alkylator/Crosslinker-VAL-083
VAL-083

Chemical Structure : VAL-083

CAS No.: 23261-20-3

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VAL-083 (Dianhydrodulcitol)

货号: PC-20967Not For Human Use, Lab Use Only.

VAL-083 (Dianhydrodulcitol) is a small alkylating molecule that induces interstrand DNA crosslinking, induces persistent DNA double-strand breaks (DSB) and cell-cycle arrest in a p53-dependent or p53-independent manner.

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5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VAL-083 (Dianhydrodulcitol) is a small alkylating molecule that induces interstrand DNA crosslinking, induces persistent DNA double-strand breaks (DSB) and cell-cycle arrest in a p53-dependent or p53-independent manner.

物理化学性质&存储条件

分子量 146.14
分子式 C6H10O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O[C@H]([C@H](O)[C@@]1(CO1)[H])[C@]2(CO2)[H]

参考文献

1. Jiménez-Alcázar M, et al. Mol Cancer Ther. 2021 Jun;20(6):1029-1038.

2. Golebiewska A, et al. Acta Neuropathol. 2020 Dec;140(6):919-949.

3. Nemeth L, et al. Cancer Chemother Rep 1972;56:593–602.

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