VA1213 | COX-2 inhibitor | Probechem Biochemicals

Chemical Structure : VA1213

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VA1213 (VA-1213)

货号: PC-26241Not For Human Use, Lab Use Only.

VA1213 is a selective cyclooxygenase-2 (COX-2) inhibitor with IC50 of 66.28 uM, suppresses tumor cells growth (HT-29 IC50=26.6 uM, 48h).

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生物&药学活性

VA1213 is a selective cyclooxygenase-2 (COX-2) inhibitor with IC50 of 66.28 uM, suppresses tumor cells growth (HT-29 IC50=26.6 uM, 48h).
VA1213 regulates cell cycle checkpoint proteins and apoptosis in colorectal cancer cells.
VA1213 impairs tumor cell migration and colony forming ability.
VA1213 impairs tumor cell response by inhibiting the MAPK, PI3K/AKT pathways and EGFR activation.

物理化学性质&存储条件

分子量	433.56
分子式	C22H24FNO3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-(1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)ethyl)thio)ethan-1-ol

参考文献

1. Valerio Ciccone, et al. Eur J Pharm Sci. 2026 Apr 1:219:107422.

VA1213 (VA-1213)

生物&药学活性

物理化学性质&存储条件

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VA1213 (VA-1213)

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物理化学性质&存储条件

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