V-9302 |CAS:1855871-76-9 Probechem Biochemicals

Chemical Structure : V-9302

CAS No.: 1855871-76-9

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V-9302 (V9302)

货号: PC-50008Not For Human Use, Lab Use Only.

V-9302 (V9302) is a competitive, selective antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 with IC50 of 9.6 uM.

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25 mg	￥2580	In stock
50 mg	￥4580	In stock
100 mg	￥7880	In stock
1 g		Get quote

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生物&药学活性

V-9302 (V9302) is a competitive, selective antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 with IC50 of 9.6 uM.
V-9302 displays 100-fold improvement in potency over γ-L-glutamyl-p-nitroanilide (GPNA).
V-9302 attenuates cancer cell growth and proliferation (CRC cell lines EC50=9-15 uM), increases cell death, and increases oxidative stress, which collectively contribute to antitumor responses in vitro and in vivo.

物理化学性质&存储条件

分子量	538.688
分子式	C34H38N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-4-(bis(2-((3-methylbenzyl)oxy)benzyl)amino)butanoic acid

参考文献

1. Schulte ML, et al. Nat Med. 2018 Jan 15. doi: 10.1038/nm.4464.

2. Schulte ML, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):1044-1047.

V-9302 (V9302)

生物&药学活性

物理化学性质&存储条件

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V-9302 (V9302)

生物&药学活性

物理化学性质&存储条件

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