V-161 | EhV-ATPase inhibitor | Probechem Biochemicals

Chemical Structure : V-161

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V-161 (V161)

货号: PC-23925Not For Human Use, Lab Use Only.

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生物&药学活性

V-161 is a potent, specific E. hirae Na+-transporting V-ATPase (EhV-ATPase) inhibitor with IC50 of 144 nM, blocks the function of Na+-transporting V-ATPase and preferentially inhibits the growth of enterococci.
V-161 binds to the interface of the c-ring and a-subunit, constituting the Na+ transport pathway in the membrane, thereby halting its rotation.
V-161 significantly suppresses VRE colonization in the small intestine of mice, having no effect on bacteria lacking this enzyme or on human cells.
V-161 inhibits vancomycin-resistant Enterococcus faecium (VRE).
V-161 inhibits the growth of E. hirae under alkaline conditions (>pH 7.5) with MIC of 4 ug/mL for both E. hirae and VRE (pH 8.5), but not under neutral or acidic conditions (V-161 selectively blocks bacterial V-ATPase function, but not human kidney cells.
V-161 significantly suppresses VRE colonization in the mouse small intestine.

物理化学性质&存储条件

分子量	251.33
分子式	C16H17N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-dimethyl-4-(5-methyl-1H-benzo[d]imidazol-2-yl)aniline

参考文献

1. Suzuki K, et al. Nat Struct Mol Biol. 2024 Nov 21. doi: 10.1038/s41594-024-01419-y.

2. Crawford CR, et al. J Biol Chem. 1998 Feb 27;273(9):5288-93.

V-161 (V161)

生物&药学活性

物理化学性质&存储条件

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V-161 (V161)

生物&药学活性

物理化学性质&存储条件

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