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首页-抗体和重组蛋白-Biosimilar Antibody-Utomilumab
Utomilumab

Chemical Structure : Utomilumab

CAS No.: 1417318-27-4

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Utomilumab (Anti-human CD137-hIgG2 mAb, human IgG2-Lambda 2; PF-05082566)

货号: PC-Ab1040Not For Human Use, Lab Use Only.

Utomilumab (PF-05082566) is a ligand-blocking antibody, binds 4-1BB between CRDs 3 and 4, a fully human monoclonal antibody (mAb) agonist that selectively binds to 4-1BB (also called CD137), a protein receptor expressed in many cancer-fighting T cells. Utomilumab (PF-05082566) binds specifically to 4-1BB (CD-137), a receptor protein found in many immune cells, such as T-cells (killer T-cells and helper T-cells) and natural killer cells..

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Utomilumab (PF-05082566) is a ligand-blocking antibody, binds 4-1BB between CRDs 3 and 4, a fully human monoclonal antibody (mAb) agonist that selectively binds to 4-1BB (also called CD137), a protein receptor expressed in many cancer-fighting T cells. Utomilumab (PF-05082566) binds specifically to 4-1BB (CD-137), a receptor protein found in many immune cells, such as T-cells (killer T-cells and helper T-cells) and natural killer cells.

物理化学性质&存储条件

分子量
分子式 Human IgG2-Lambda 2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Utomilumab; PF-05082566; PF 05082566; 1417318-27-4; 4-1BB/CD137 antibody; 4-1BB/CD137; CD137 antigen agonists; PF-2566; PF-5082566

参考文献

1. 1, Chin SM, et al. Nat Commun. 2018 Nov 8;9(1):4679. 2, Segal NH, et al. Clin Cancer Res. 2018 Apr 15;24(8):1816-1823. 3, Tolcher AW, et al. Clin Cancer Res. 2017 Sep 15;23(18):5349-5357. 4, Fisher TS, et al. Cancer Immunol Immunother. 2012 Oct;61(10):1721-33.

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