Upadacitinib (ABT-494) | JAK1 inhibitor | Probechem Biochemicals

Chemical Structure : Upadacitinib

CAS No.: 1310726-60-3

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Upadacitinib (ABT-494, ABT494)

货号: PC-45653Not For Human Use, Lab Use Only.

Upadacitinib (ABT-494) is a potent and selective JAK1 inhibitor with celluar IC50 of 8 nM, biochemical IC50 of 40 nM.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg	￥3780	In stock
250 mg		Get quote
250 mg		Get quote

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生物&药学活性

Upadacitinib (ABT-494) is a potent and selective JAK1 inhibitor with celluar IC50 of 8 nM, biochemical IC50 of 40 nM.
Upadacitinib (ABT-494) displays 74-fold and 50-fold selectivity over JAK2 and JAK3, respectively.
Upadacitinib (ABT-494) is a second-generation JAK inhibitor in development for rheumatoid arthritis.

物理化学性质&存储条件

分子量	380.3676
分子式	C17H19F3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 22 mg/mL
Chemical Name/SMILES	1-Pyrrolidinecarboxamide, 3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-, (3S,4R)-

参考文献

1. Genovese MC, et al. Arthritis Rheumatol. 2016 Dec;68(12):2857-2866.

2. Kremer JM, et al. Arthritis Rheumatol. 2016 Dec;68(12):2867-2877.

3. Mohamed MF, et al. Clin Pharmacokinet. 2016 Dec;55(12):1547-1558.

Upadacitinib (ABT-494, ABT494)

生物&药学活性

物理化学性质&存储条件

参考文献

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Upadacitinib (ABT-494, ABT494)

生物&药学活性

物理化学性质&存储条件

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