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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-Up284
Up284

Chemical Structure : Up284

CAS No.: 2648549-50-0

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Up284 (Up 284)

货号: PC-22711Not For Human Use, Lab Use Only.

Up284 is a small molecule inhibitor of proteasome's 19S Regulatory Particle (RP) ubiquitin receptor RPN13 (ADRM1, hRPN13, or GP110), covalently binds RPN13 and induces rapid apoptosis in ovarian cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Up284 is a small molecule inhibitor of proteasome's 19S Regulatory Particle (RP) ubiquitin receptor RPN13 (ADRM1, hRPN13, or GP110), covalently binds RPN13 and induces rapid apoptosis in ovarian cancer cells.

物理化学性质&存储条件

分子量 365.44
分子式 C24H19N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,4'-((1E,1'E)-(2-oxo-7-azaspiro[3.5]nonane-1,3-diylidene)bis(methaneylylidene))dibenzonitrile

参考文献

1. Anchoori RK, et al. PLoS One. 2023 Jun 14;18(6):e0285221.

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