UoS12258 |CAS:875927-64-3 Probechem Biochemicals

Chemical Structure : UoS12258

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UoS12258 (UoS 12258;UoS-12258)

货号: PC-35565Not For Human Use, Lab Use Only.

UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6.

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生物&药学活性

UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6.
UoS12258 displays excellent wide selectivity against a wide range of other ion channels (including hERG, NMDA, and kainate channels), enzymes, and GPCRs.
UoS12258 displays a minimum effective concentration of approximately 10 nM in vitro and enhances AMPA receptor-mediated synaptic transmission at an estimated free brain concentration of approximately 15 nM in vivo.
UoS12258 exhibits cognition enhancing properties in several rat behavioural models.

物理化学性质&存储条件

分子量	334.409
分子式	C17H19FN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro 1H-inden-2-yl]-2-propanesulfonamide

参考文献

1. Ward SE, et al. J Med Chem. 2010 Aug 12;53(15):5801-12.

2. Ward SE, et al. Br J Pharmacol. 2017 Mar;174(5):370-385.

UoS12258 (UoS 12258;UoS-12258)

生物&药学活性

物理化学性质&存储条件

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UoS12258 (UoS 12258;UoS-12258)

生物&药学活性

物理化学性质&存储条件

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