UniPR1449 | EphA receptor inhibitor | Probechem Biochemicals

Chemical Structure : UniPR1449

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UniPR1449 (UniPR-1449)

货号: PC-25847Not For Human Use, Lab Use Only.

UniPR1449 is a selective EphA receptor inhibitor with IC50 of 8.1 uM in EphA2-ephrin-A1 displacement assay, inhibits the interaction of ephrin-A1 with all EphA receptor subtypes (IC50=5.5-11 uM).

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生物&药学活性

UniPR1449 is a selective EphA receptor inhibitor with IC50 of 8.1 uM in EphA2-ephrin-A1 displacement assay, inhibits the interaction of ephrin-A1 with all EphA receptor subtypes (IC50=5.5-11 uM).
UniPR1449 does not affect the binding of ephrin-B1 with EphB receptor subtypes.
UniPR1449 blocks ephrin-A1-induced EphA2 phosphorylation, internalization, and degradation in GBM cell lines.
significantly reduces proliferation and S-phase entry in patient-derived GSCs.
UniPR1449 impairs VEGF-induced angiogenesis in the chick chorioallantoic membrane (CAM) assay.

物理化学性质&存储条件

分子量	700.94
分子式	C41H52N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Na-((R)-4-((3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl)-1-(phenylsulfonyl)-L-tryptophan

参考文献

1. Guidetti L, et al. Eur J Med Chem. 2024 Oct 5;276:116681.

2. Zappia A, et al. Biochem Pharmacol. 2025 Dec;242(Pt 4):117398.

UniPR1449 (UniPR-1449)

生物&药学活性

物理化学性质&存储条件

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UniPR1449 (UniPR-1449)

生物&药学活性

物理化学性质&存储条件

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