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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Beta-secretase (BACE)-Umibecestat
Umibecestat

Chemical Structure : Umibecestat

CAS No.: 1387560-01-1

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Umibecestat (CNP520, CNP-520)

货号: PC-60085Not For Human Use, Lab Use Only.

Umibecestat (CNP520) is a potent, selective, and efficacious β-Secretase (BACE1) inhibitor with IC50 of 11 nM and 30 nM for BACE1 and BACE2, respectively.

规格 价格 库存 数量
5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Umibecestat (CNP520) is a potent, selective, and efficacious β-Secretase (BACE1) inhibitor with IC50 of 11 nM and 30 nM for BACE1 and BACE2, respectively.
Umibecestat (CNP520) reduced significantly Aβ levels in mice and rats in acute and chronic treatment regimens without any side effects.

物理化学性质&存储条件

分子量 513.801
分子式 C19H15ClF7N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-5-fluoropyridin-2-yl)-3-chloro-5-(trifluoromethyl)picolinamide

参考文献

1. Neumann U, et al. EMBO Mol Med. 2018 Sep 17. pii: e9316. doi: 10.15252/emmm.201809316.

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