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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Udenafil
Udenafil

Chemical Structure : Udenafil

CAS No.: 268203-93-6

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Udenafil (DA-8159, DA8159)

货号: PC-45441Not For Human Use, Lab Use Only.

Udenafil (DA-8159) is a potent and selective phosphodiesterase 5 (PDE5) inhibitor, inhibits PDE5 activity in rabbit and human platelets with IC50 of 5.84 nM and 8.2 nM, respectively.

规格 价格 库存 数量
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
250 mg ￥30 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Udenafil (DA-8159) is a potent and selective phosphodiesterase 5 (PDE5) inhibitor, inhibits PDE5 activity in rabbit and human platelets with IC50 of 5.84 nM and 8.2 nM, respectively.
Udenafil (DA-8159) inhibits PDE 5-catalyzed cGMP hydrolysis.
Udenafil (DA-8159) significantly stimulated the accumulation of cGMP.
Udenafil (DA-8159) displays> 100-fold selectivity over PDE 1, PDE 2, PDE 3 and PDE 6.
Udenafil (DA-8159) enhanced the relaxation of the smooth muscles in the normal rabbit corpus cavernosum. 
Udenafil (DA-8159)  induced a dose-dependent penile erection in diabetic rabbits.

物理化学性质&存储条件

分子量 516.6561
分子式 C25H36N6O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 33 mg/mL
Chemical Name/SMILES

Benzenesulfonamide, 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-propoxy-

参考文献

1. Salem EA, et al. Curr Opin Investig Drugs. 2006 Jul;7(7):661-9.

2. Lee CH, et al. J Sex Med. 2010 Jul;7(7):2564-71.

3. Kang HE, et al. Br J Pharmacol. 2009 Mar;156(6):1009-18.

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