UbcH5c inhibitor DHPO | UbcH5c inhibitor | Probechem Biochemicals

Chemical Structure : UbcH5c inhibitor DHPO

CAS No.: 33627-28-0

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UbcH5c inhibitor DHPO (DHPO, Britanin, NSC145913, 2-Acetylflexuosin A)

货号: PC-72140Not For Human Use, Lab Use Only.

UbcH5c inhibitor DHPO (Britanin, NSC145913) is a small molecule UbcH5c inhibitor, directly targets UbcH5c with KD of 37.5 uM.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

UbcH5c inhibitor DHPO (Britanin, NSC145913) is a small molecule UbcH5c inhibitor, directly targets UbcH5c with KD of 37.5 uM.
DHPO effectively engaged by the UbcH5c protein in both Panc1 and SW1990 cells.
DHPO exerts significant growth inhibition in pancreatic cancer cells in vitro (IC50=2.3-8.5 uM), prevents the migration and invasion of both Panc1 and SW1990 cells.
DHPO inhibits pancreatic cancer cell growth and metastasis by inhibiting the NF-κB pathway.
DHPO suppresses orthotopic pancreatic tumor growth in vivo, without causing significant host toxicity.
DHPO prevents metastasis of pancreatic cancer in vivo.

物理化学性质&存储条件

分子量	366.4
分子式	C19H26O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,7-Dihydroxy-4a,8-dimethyl-3-methylidene-2-oxododecahydroazuleno[6,5-b]furan-4,9-diyl diacetate

参考文献

1. Simin Qi, et al. Mol Cancer. 2022 Mar 10;21(1):70.

UbcH5c inhibitor DHPO (DHPO, Britanin, NSC145913, 2-Acetylflexuosin A)

生物&药学活性

物理化学性质&存储条件

参考文献

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UbcH5c inhibitor DHPO (DHPO, Britanin, NSC145913, 2-Acetylflexuosin A)

生物&药学活性

物理化学性质&存储条件

参考文献

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