UbcH5c-IN-6d |CAS:2123480-72-6 Probechem Biochemicals

Chemical Structure : UbcH5c-IN-6d

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UbcH5c-IN-6d (UbcH5c inhibitor 6d)

货号: PC-60354Not For Human Use, Lab Use Only.

UbcH5c-IN-6d is a potent, specific, orally bioactive small-molecule inhibitor of ubiquitin-conjugating enzyme UbcH5c with Kd of 283 nM.

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生物&药学活性

UbcH5c-IN-6d is a potent, specific, orally bioactive small-molecule inhibitor of ubiquitin-conjugating enzyme UbcH5c with Kd of 283 nM.
UbcH5c-IN-6d suppresses the activation of the NF-κB signaling pathway by selectively covalently binding to the Cys85 residue of UbcH5c.
UbcH5c-IN-6d exhibits potent anti-inflammatory activity against complete Freund’s adjuvant-induced adjuvant arthritis in vivo.

物理化学性质&存储条件

分子量	413.31
分子式	C22H21BrO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aS,9bR)-8-((2-Bromobenzyl)oxy)-6,9-dimethyl-3-methylene-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one

参考文献

1. Chen H, et al. J Med Chem. 2017 Aug 24;60(16):6828-6852.

UbcH5c-IN-6d (UbcH5c inhibitor 6d)

生物&药学活性

物理化学性质&存储条件

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UbcH5c-IN-6d (UbcH5c inhibitor 6d)

生物&药学活性

物理化学性质&存储条件

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