UZH1a

Chemical Structure : UZH1a

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货号: PC-20135Not For Human Use, Lab Use Only.

UZH1a is a potent, selective and cell‐permeable inhibitor of METTL3 with IC50 of 0.28 uM, 100-fold more potent than enantiomer UZH1b.

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生物&药学活性

UZH1a is a potent, selective and cell‐permeable inhibitor of METTL3 with IC50 of 0.28 uM, 100-fold more potent than enantiomer UZH1b.
UZH1a demonstrated high selectivity towards other protein methyltransferases (as well as several promiscuous protein kinases) at 10 uM.
UZH1a inhibited cellular m6A levels in mRNA fraction in the leukemia cell line MOLM‐13.

物理化学性质&存储条件

分子量	558.73
分子式	C32H42N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-((4,4-dimethylpiperidin-1-yl)methyl)-2-hydroxybenzamide

参考文献

1. Moroz-Omori EV, et al. ChemMedChem. 2021 Oct 6;16(19):3035-3043.

UZH1a

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物理化学性质&存储条件

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UZH1a

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