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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Acetylcholinesterase (AChE)-UW-MD-95
UW-MD-95

Chemical Structure : UW-MD-95

CAS No.: 1393714-22-1

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UW-MD-95

货号: PC-22544Not For Human Use, Lab Use Only.

UW‐MD‐95 is a potent pseudo‐irreversible butyrylcholinesterase (BChE) inhibitor with IC50 of 60 nM, does not inhibit AChE, shows potent neuroprotective in the Aβ25‐35 model of AD.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

UW‐MD‐95 is a potent pseudo‐irreversible butyrylcholinesterase (BChE) inhibitor with IC50 of 60 nM, does not inhibit AChE, shows potent neuroprotective in the Aβ25‐35 model of AD.

物理化学性质&存储条件

分子量 407.56
分子式 C25H33N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

13-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[1,2-b]quinazolin-10-yl heptylcarbamate

参考文献

1. Allison Carles, et al. CNS Neurosci Ther. 2024 Jun;30(6):e14814.

2. Darras FH, et al. ACS Med Chem Lett. 2012;3:914‐919.

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