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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-UVI5008
UVI5008

Chemical Structure : UVI5008

CAS No.: 1071822-30-4

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UVI5008 (UVI-5008)

货号: PC-26064Not For Human Use, Lab Use Only.

UVI5008 is a small molecule epigenetic modifier/modulator that inhibits histone deacetylases, sirtuins, and DNA methyltransferases, affects the death receptor (DR) pathway and reactive oxygen species (ROS) production in cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

UVI5008 is a small molecule epigenetic modifier/modulator that inhibits histone deacetylases, sirtuins, and DNA methyltransferases, affects the death receptor (DR) pathway and reactive oxygen species (ROS) production in cancer cells.
UVI5008 inhibits MRSA by interfering with bacterial gyrase.
UVI5008 effectively inhibits both wild-type BTK and the C481S mutated BTK isoform, commonly associated with BTK-inhibitor resistance in CLL.

物理化学性质&存储条件

分子量 710.46
分子式 C26H26Br2N6O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2E,2'E)-N,N'-(disulfanediylbis(ethane-2,1-diyl))bis(3-(5-bromo-1H-indol-3-yl)-2-(hydroxyimino)propanamide)

参考文献

1. Franci G, et al. Sci Rep. 2018 Sep 3;8(1):13117.

2. Dell'Aversana C, et al. J Hematol Oncol. 2026 Feb 22. doi: 10.1186/s13045-026-01784-9.

3. Nebbioso A, et al.

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