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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-RAR/RXR-UVI 2008
UVI 2008

Chemical Structure : UVI 2008

CAS No.: 1504556-86-8

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UVI 2008 (UVI2008)

货号: PC-70296Not For Human Use, Lab Use Only.

UVI 2008 is a RARβ/γ agonist originated from TTNPB, is also a selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10) with IC50 of 6.1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    UVI 2008 is a RARβ/γ agonist originated from TTNPB, is also a selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10) with IC50 of 6.1 uM.
    UVI 2008 shows >10-fold selectivity over the closely related aldose reductase (AR, IC50=70 uM).

    物理化学性质&存储条件

    分子量 427.382
    分子式 C24H27BrO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-3-bromo-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)benzoic acid

    参考文献

    1. Ruiz FX, et al. Chem Biol Interact. 2017 Feb 1. pii: S0009-2797(17)30109-6.

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