UU-T03 |CAS:1586007-00-2 Probechem Biochemicals

Chemical Structure : UU-T03

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UU-T03 (UU-T 03)

货号: PC-61801Not For Human Use, Lab Use Only.

UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM.

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生物&药学活性

UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM。
UU-T03 exhibits growth inhibition of SW480 cells with IC50 of 10.77 uM。
UU-T03 downregulates the transcription of AXIN2, LGR5, cyclin D1, and c-Myc in dose-dependent manners in SW480 cells.

物理化学性质&存储条件

分子量	721.204
分子式	C37H41ClN4O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-ethyl 1-methyl ((S)-2-((S)-2-(2-(5-chloro-1H-indol-2-yl)acetamido)-3-(naphthalen-2-yl)propanamido)-4-ethoxy-4-oxobutanoyl)-L-glutamate

参考文献

1. Huang Z, et al. ACS Chem Biol. 2014 Jan 17;9(1):193-201.

UU-T03 (UU-T 03)

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物理化学性质&存储条件

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UU-T03 (UU-T 03)

生物&药学活性

物理化学性质&存储条件

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