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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Beta-catenin-UU-T02
UU-T02

Chemical Structure : UU-T02

CAS No.: 1500080-17-0

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UU-T02 (UU-T 02)

货号: PC-61800Not For Human Use, Lab Use Only.

UU-T02 is a novel potent, selective small-molecule inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    UU-T02 is a novel potent, selective small-molecule inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM.
    UU-T02 displays 63-fold and 175-fold selectivity over β-catenin/E-cadherin and β-catenin/APC interactions, respectively.

    物理化学性质&存储条件

    分子量 665.096
    分子式 C33H33ClN4O9
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-((S)-3-carboxy-2-((S)-2-(2-(5-chloro-1H-indol-2-yl)acetamido)-3-(naphthalen-2-yl)propanamido)propanamido)-5-methoxy-5-oxopentanoic acid

    参考文献

    1. Huang Z, et al. ACS Chem Biol. 2014 Jan 17;9(1):193-201.

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