UTX-143 | NHE5 inhibitor | Probechem Biochemicals

Chemical Structure : UTX-143

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UTX-143 (UTX143)

货号: PC-21711Not For Human Use, Lab Use Only.

UTX-143 is a potent, selective sodium-hydrogen exchange subtype 5 (NHE5) inhibitor with IC50 of 3.11 uM, 80-fold selective over NHE1.

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1 g		Get quote

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生物&药学活性

UTX-143 is a potent, selective sodium-hydrogen exchange subtype 5 (NHE5) inhibitor with IC50 of 3.11 uM, 80-fold selective over NHE1.
UTX-143 shows potent cytotoxic activity against HT-1080 cells (IC50=15.4 uM), with no cytotoxic activity against normal cells at up to 100 μM.
UTX-143 also shows broad cytotoxic activity against esophageal squamous cell carcinoma and gastric cancer cell lines in WST-8 assays.
UTX-143 (20 uM) suppresses MMP-9 expression and MMP-2 activation in mouse metastatic melanoma cells.
UTX-143 (25 uM) has a strong invasion-inhibiting effect on HT-1080 cells.

物理化学性质&存储条件

分子量	343.39
分子式	C16H21N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-N-carbamimidoyl-5-((2-hydroxyethyl)(methyl)amino)-6-(p-tolyl)pyrazine-2-carboxamide

参考文献

1. Yusei Shinohara, et al. Bioorg Med Chem. 2024 Jan 14:99:117603.

UTX-143 (UTX143)

生物&药学活性

物理化学性质&存储条件

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UTX-143 (UTX143)

生物&药学活性

物理化学性质&存储条件

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