UT-59 | Scap inhibitor | Probechem Biochemicals

Chemical Structure : UT-59

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UT-59 (Scap inhibitor UT-59)

货号: PC-21786Not For Human Use, Lab Use Only.

UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.

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生物&药学活性

UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.
UT-59 dramatically reduces mRNAs of target genes of SREBP1 (Insig-1, ACSS2, ACC1, FASN, SCD1) and SREBP-2 (HMG-CoA synthase, HMG-CoA reductase, LDL receptor, PCSK9, and others), reduces lipid synthesis.
UT-59 is not generally toxic to cells.
UT-59 binds to Scap and changes its conformation, promoting Scap's binding to Insig, which blocks ER-to-Golgi transport of Scap.
UT-59 selectively blocks Scap/SREBP transport without blocking the general process of ER-to-Golgi transport, and shows high specificity in competing for cholesterol binding to Scap's Loop1.
UT-59 can block SREBP processing in animals and sets the stage for testing the effects of specifically blocking the synthesis of fatty acids, triglycerides, and cholesterol in animal models of lipid dysregulation.
UT-59 is a promising candidate non-sterol small molecule that specifically suppresses the ER-to-Golgi transport of SREBPs in a manner similar to cholesterol.

物理化学性质&存储条件

分子量	406.44
分子式	C22H22N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4-(3-(4-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)phenyl)ureido)benzoate

参考文献

1. Xu S, et al. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2318024121.

UT-59 (Scap inhibitor UT-59)

生物&药学活性

物理化学性质&存储条件

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UT-59 (Scap inhibitor UT-59)

生物&药学活性

物理化学性质&存储条件

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