UT-143 | Androgen Receptor inhibitor | Probechem Biochemicals

Chemical Structure : UT-143

CAS No.: 2698320-33-9

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UT-143 (UT143)

货号: PC-49597Not For Human Use, Lab Use Only.

UT-143 (UT143) is a small-molecule selective androgen receptor (AR) irreversible covalent antagonist, covalently and selectively bind to C406 and C327 in the AF-1 region of AR.

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2 mg	￥2580	In stock
5 mg	￥4280	In stock
10 mg	￥7280	In stock
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100 mg		Get quote

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生物&药学活性

UT-143 (UT143) is a small-molecule selective androgen receptor (AR) irreversible covalent antagonist, covalently and selectively bind to C406 and C327 in the AF-1 region of AR.
UT-143 interferes liquid–liquid phase separation (LLPS), causes chromatin condensation and dissociation of AR-V7 interactome.
UT-143 possesses drug-like pharmacokinetics and metabolism properties and inhibits PCa cell proliferation and tumor growth.

物理化学性质&存储条件

分子量	462.389
分子式	C20H17F3N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (S)-2-(((3-(4-cyano-1H-pyrazol-1-yl)-1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)amino)-2-methyl-1-oxopropan-2-yl)oxy)methyl)acrylate

参考文献

1. Thiyagarajan T, et al. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2211832120.

UT-143 (UT143)

生物&药学活性

物理化学性质&存储条件

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UT-143 (UT143)

生物&药学活性

物理化学性质&存储条件

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