UT-11 | mPGES-1 inhibitor | Probechem Biochemicals

Chemical Structure : UT-11

CAS No.:

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UT-11 (mPGES-1 inhibitor UT-11)

货号: PC-20720Not For Human Use, Lab Use Only.

UT-11 is a potent microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, inhibits PGE2 production from human SK-N-AS and murine BV2 cells induced by LPS with IC50 of 0.1 and 2.0 uM, respectively.

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5 mg	￥2780	In stock
10 mg	￥4280	In stock
25 mg	￥7280	In stock
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100 mg		Get quote

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生物&药学活性

UT-11 is a potent microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, inhibits PGE2 production from human SK-N-AS and murine BV2 cells induced by LPS with IC50 of 0.1 and 2.0 uM, respectively.
Treatment with UT-11 (10 mg/kg) significantly blunted the upregulation of mPGES-1 induced by LPS in the hippocampus.
UT-11 also blunted thte upregulation of other inflammatory genes (IL-6, TNF-α, CCL2, CCL3, CCL4) in the hippocampus in mice.

物理化学性质&存储条件

分子量	400.32
分子式	C17H19Cl2N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(5,6-dichlorobenzo[d]thiazol-2-yl)-N-(tetrahydrofuran-3-yl)piperidine-4-carboxamide

参考文献

1. Madison N. Sluter, et al. ACS Pharmacol Transl Sci. 2023 Mar 21;6(4):587-599.

UT-11 (mPGES-1 inhibitor UT-11)

生物&药学活性

物理化学性质&存储条件

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UT-11 (mPGES-1 inhibitor UT-11)

生物&药学活性

物理化学性质&存储条件

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