USP8 inhibitor RA-9 | USP8 inhibitor | Probechem Biochemicals

Chemical Structure : USP8 inhibitor RA-9

CAS No.: 919091-63-7

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USP8 inhibitor RA-9 (RA-9)

货号: PC-72534Not For Human Use, Lab Use Only.

USP8 inhibitor RA-9 is a small molecule USP8 inhibitor.

规格	价格	库存
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg	￥2480	In stock
250 mg		Get quote

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生物&药学活性

USP8 inhibitor RA-9 is a small molecule USP8 inhibitor.
USP8 inhibitor RA-9 inhibits colony formation of breast, ovarian and cervical cancer cells with IC50 of <100 nM, completely abrogating colony formation at 0.3 uM.
USP8 inhibitor RA-9 inhibits deubiqutinating enzymes (DUB) and alters expression of DUB-regulated oncogenes and tumor suppressors.
USP8 inhibitor RA-9 directly suppress activities of major cellular DUB, such as UCH-L1, UCH-L3, USP2, USP5 and USP8, but do not inhibit Ataxin-3, A20CD, BAP1, Otubain 1, USP7/HAUSP or USP14.

物理化学性质&存储条件

分子量	365.34
分子式	C19H15N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3E,5E)-3,5-Bis(4-nitrobenzylidene)piperidin-4-one

参考文献

1. Issaenko OA, et al. Cell Cycle. 2012 May 1;11(9):1804-17.

2. Treppiedi D, et al. Endocr Relat Cancer. 2021 Jun 28;28(8):573-582

3. Zhu Y, et al. Aging (Albany NY). 2021 Jun 3;13(11):14999-15012.

USP8 inhibitor RA-9 (RA-9)

生物&药学活性

物理化学性质&存储条件

参考文献

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USP8 inhibitor RA-9 (RA-9)

生物&药学活性

物理化学性质&存储条件

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