USP7 inhibitor X36

Chemical Structure : USP7 inhibitor X36

加入收藏

货号: PC-22885Not For Human Use, Lab Use Only.

USP7 inhibitor X36 is a potent, selective and orally active USP7 inhibitor with IC50 of 64.5 nM, shows no activity against a panel of 9 DUBs including USP47.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

USP7 inhibitor X36 is a potent, selective and orally active USP7 inhibitor with IC50 of 64.5 nM, shows no activity against a panel of 9 DUBs including USP47.
X36 (100 mg/kg, p.o.) exerted in vivo antitumor activity, probably through modulating immunity in the colons tumor-bearing C57BL/6J mice.
X36 suppressed tumor growth probably through enhancement of the antitumor immunity response by upregulation of tumor-killing CD8+ T, NK, and NKT cells and downregulation of immunosuppressive Tregs and MDSCs in the tumor microenvironment.

物理化学性质&存储条件

分子量	548.02
分子式	C29H27ClFN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((1-(2-Chloro-4-(furan-2-yl)benzyl)-4-hydroxypiperidin-4-yl)methyl)-3-(4-fluorophenyl)-2-methyl-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

参考文献

1. Xing Li, et al. J Med Chem. 2022 Dec 22;65(24):16622-16639.