USP7-797 | USP7 inhibitor | Probechem Biochemicals

Chemical Structure : USP7-797

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USP7-797 (RAPT41)

货号: PC-38191Not For Human Use, Lab Use Only.

USP7-797 (RAPT41) is a novel potent selective inhibitor of USP7 with IC50 of 0.44 nM.

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生物&药学活性

USP7-797 (RAPT41) is a novel potent selective inhibitor of USP7 with IC50 of 0.44 nM.
USP7-797 (RAPT41) inhibits the growth of p53-mutant small cell lung cancer cell line H526 at a CC50 of 450 nM.
USP7-797 (RAPT41) demonstrates tumor growth inhibition in both p53 wildtype and p53 mutant cancers.

物理化学性质&存储条件

分子量	510.049
分子式	C27H28ClN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((7-(5-chloro-3-methyl-2-(((R)-morpholin-2-yl)methyl)phenyl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione

参考文献

1. Yamini M Ohol, et al. Mol Cancer Ther. 2020 Oct;19(10):1970-1980.

2. Paul R Leger, et al. J Med Chem. 2020 May 28;63(10):5398-5420.

USP7-797 (RAPT41)

生物&药学活性

物理化学性质&存储条件

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USP7-797 (RAPT41)

生物&药学活性

物理化学性质&存储条件

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