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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-USP5 inhibitor 64
USP5 inhibitor 64

Chemical Structure : USP5 inhibitor 64

CAS No.: 2851040-81-6

USP5 inhibitor 64 (USP5-IN-1)

货号: PC-72414Not For Human Use, Lab Use Only.

USP5 inhibitor 64 is a selective chemical probe (inhibitor) against USP5 deubiquitinase, binds to the USP5 ZnF-UBD (zinc-finger ubiquitin binding domain) with KD of 2.8 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

USP5 inhibitor 64 is a selective chemical probe (inhibitor) against USP5 deubiquitinase, binds to the USP5 ZnF-UBD (zinc-finger ubiquitin binding domain) with KD of 2.8 uM.
USP5 inhibitor 64 is selective over nine proteins containing structurally similar ZnF-UBD domains.
USP5 inhibitor 64 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate in an in vitro assay.

物理化学性质&存储条件

分子量 437.895
分子式 C19H20ClN3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

Chemical Name/SMILES

(5-((4-(4-chlorophenyl)piperidin-1-yl)sulfonyl)picolinoyl)glycine

参考文献

1. Mandeep K Mann, et al. J Med Chem. 2021 Oct 28;64(20):15017-15036.

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