USP30i-3

Chemical Structure : USP30i-3

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货号: PC-23862Not For Human Use, Lab Use Only.

USP30i-3 is a potent, selective small molecule USP30 inhibitor with IC50 of 21 nM, selective over other DUBs (IC50=250->3000 nM) with exception of USP6 (IC50=60 nM).

规格	价格	库存	数量
50 mg		Get quote
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250 mg		Get quote

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生物&药学活性

USP30i-3 is a potent, selective small molecule USP30 inhibitor with IC50 of 21 nM, selective over other DUBs (IC50=250->3000 nM) with exception of USP6 (IC50=60 nM).
USP30i-3 (3 µM) enhanced mitophagy in control and PARK2 KO neurons subjected to mitochondrial damage by CCCP. USP30i-3 reduced ROS levels in compromised (either by CCCP or parkin KO) neurons.
In TH-, but not TH+ neurons, 3 µM USP30i-3 reduced HSP60 areas in the absence of CCCP-induced mitochondrial damage, demonstrating a stronger effect of USP30 inhibition on basal mitophagy in the PARK2 KO TH- neurons.

物理化学性质&存储条件

分子量	325.80
分子式	C18H16ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2'-chloro-N-(1-cyanopyrrolidin-3-yl)-[1,1'-biphenyl]-4-carboxamide

参考文献

1. Okarmus J, et al. Cell Death Dis. 2024 Jan 15;15(1):52.

2. Patent WO2016156816 A1.

USP30i-3

生物&药学活性

物理化学性质&存储条件

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USP30i-3

生物&药学活性

物理化学性质&存储条件

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