USP30Inh-1 | USP30 inhibitor | Probechem Biochemicals

Chemical Structure : USP30Inh-1

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USP30Inh-1 (USP30 inhibitor 1)

货号: PC-72254Not For Human Use, Lab Use Only.

USP30Inh-1 is a potent, selective small molecule USP30 inhibitor with IC50 of 15-30 nM (inhibition of USP30-mediated cleavage of Ub-Rho110).

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

USP30Inh-1 is a potent, selective small molecule USP30 inhibitor with IC50 of 15-30 nM (inhibition of USP30-mediated cleavage of Ub-Rho110).
USP30Inh-1 is anticipated to form a covalent linkage with the catalytic cysteine within the USP30 active site.
USP30Inh-1 demonstrated good selectivity against >40 known DUB enzymes at 1 uM.
USP30Inh-1 (1-10 uM) enhances mitoKeima signal in SHSY5Y cell, increases p-Ser65-Ub in dopaminergic neurones and astrocytes, as well as in Parkin heterozygote fibroblasts.

物理化学性质&存储条件

分子量	325.372
分子式	C17H19N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1-cyanopyrrolidin-3-yl)-3-methoxy-4-(1-methyl-1H-pyrazol-4-yl)benzamide

参考文献

1. Tsefou E, et al. Biochem J. 2021 Dec 10;478(23):4099-4118.

USP30Inh-1 (USP30 inhibitor 1)

生物&药学活性

物理化学性质&存储条件

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USP30Inh-1 (USP30 inhibitor 1)

生物&药学活性

物理化学性质&存储条件

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