USP28 inhibitor 19

Chemical Structure : USP28 inhibitor 19

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货号: PC-20592Not For Human Use, Lab Use Only.

USP28 inhibitor 19 is a potent, selective USP28 inhibitor with IC50 of 1.1 uM, does not inhibit USP7 and LSD1 (IC50>100 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

USP28 inhibitor 19 is a potent, selective USP28 inhibitor with IC50 of 1.1 uM, does not inhibit USP7 and LSD1 (IC50>100 uM).
USP28 inhibitor 19 exerted good cell inhibitory activities against HGC-27 and MKN45 cells (IC50=0.61 and 1.49 μmol/L, respectively).
USP28 inhibitor 19 (20 uM) decreased expression of USP28 in HGC-27 cells, thus leading to decreased expression of its substrates LSD1 and total c-Myc.
USP28 inhibitor 19 induced cellular degradation of USP28, LSD1 and total c-Myc in HGC-27 cells.
USP28 inhibitor 19 inhibited colony formation and proliferation of gastric cancer cells, induced cell apoptosis and cell cycle arrest in HGC-27 cells.

物理化学性质&存储条件

分子量	377.90
分子式	C16H20ClN7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(3-(4-chlorobenzyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)ethane-1,2-diamine

参考文献

1. Zhenzhen Liu, et al. Acta Pharm Sin B. 2020 Aug;10(8):1476-1491.