USP25 and 28 inhibitor AZ2 | USP25/USP28 inhibitor | Probechem Biochemicals

Chemical Structure : USP25 and 28 inhibitor AZ2

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USP25 and 28 inhibitor AZ2 (AZ2)

货号: PC-60026Not For Human Use, Lab Use Only.

USP25 and 28 inhibitor AZ2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

USP25 and 28 inhibitor AZ2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.
USP25 and 28 inhibitor AZ2 shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.).
USP25 and 28 inhibitor AZ2 demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines.

物理化学性质&存储条件

分子量	420.226
分子式	C17H17BrF3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((5-bromo-2-((3-(trifluoromethoxy)benzyl)oxy)benzyl)amino)ethan-1-ol

参考文献

1. Wrigley JD, et al. ACS Chem Biol. 2017 Nov 28. doi: 10.1021/acschembio.7b00334.

USP25 and 28 inhibitor AZ2 (AZ2)

生物&药学活性

物理化学性质&存储条件

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USP25 and 28 inhibitor AZ2 (AZ2)

生物&药学活性

物理化学性质&存储条件

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