URML-3881 | MEK inhibitor | Probechem Biochemicals

Chemical Structure : URML-3881

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URML-3881 (URML3881)

货号: PC-72995Not For Human Use, Lab Use Only.

URML-3881 (URML3881) is a potent, specific MEK1/2 inhibitor IC50 of 30 nM in a cell-free kinase inhibition assay.

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100 mg		Get quote

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生物&药学活性

URML-3881 (URML3881) is a potent, specific MEK1/2 inhibitor IC50 of 30 nM in a cell-free kinase inhibition assay.
URML-3881 shows no inhibition among a panel of other kinases including MEK 3 and MEK5, which are activated in alternative MAPK signaling pathways.
URML-3881 reduces MAPK pathway activity in clear cell ovarian cancer (CCOC).
URML-3881 causes reduced CCOC viability due to induction of tumor cell apoptosis and inhibition of proliferation.
URML-3881 abrogates cisplatin-induced prosurvival MAPK signaling in CCOC, resulting in durable and dramatic tumor regression in vivo.

物理化学性质&存储条件

分子量	490.292
分子式	C16H16FIN4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1,1-dioxidothiomorpholino)-3-((2-fluoro-4-iodophenyl)amino)isonicotinamide

参考文献

1. Rowswell-Turner RB, et al. Transl Oncol. 2019 Jul;12(7):917-924.

URML-3881 (URML3881)

生物&药学活性

物理化学性质&存储条件

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URML-3881 (URML3881)

生物&药学活性

物理化学性质&存储条件

参考文献

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