URMC-099 | MLK3 inhibitor | Probechem Biochemicals

Chemical Structure : URMC-099

CAS No.: 1229582-33-5

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URMC-099 (URMC099)

货号: PC-43118Not For Human Use, Lab Use Only.

URMC-099 is a potent, orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3 (MLK3) with IC50 of 14 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

URMC-099 is a potent, orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3 (MLK3) with IC50 of 14 nM.
URMC-099 shows >90% inhibition against 111 kinases in a panel of 442 kinases at 1 uM.
URMC-099 likely functions in HIV-1 associated neurocognitive disorders (HAND) preclinical models by inhibiting multiple kinase pathways, including MLK3 and LRRK2 (IC50=11 nM).
URMC-099 inhibits LPS-induced TNFα release in microglial cells, HIV-1 Tat-induced release of cytokines in human monocytes and up-regulation of phospho-JNK in Tat-injected brains of mice.

物理化学性质&存储条件

分子量	421.5368
分子式	C27H27N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	1H-Pyrrolo[2,3-b]pyridine, 3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-

参考文献

1. Marker DF, et al. J Neurosci. 2013 Jun 12;33(24):9998-10010.

2. Goodfellow VS, et al. J Med Chem. 2013 Oct 24;56(20):8032-48.

3. Zhang G, et al. Nanomedicine. 2016 Jan;12(1):109-22.

4. Polesskaya O, et al. Mol Immunol. 2014 Apr;58(2):214-22.

URMC-099 (URMC099)

生物&药学活性

物理化学性质&存储条件

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URMC-099 (URMC099)

生物&药学活性

物理化学性质&存储条件

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