URB937 |CAS:1357160-72-5 Probechem Biochemicals

Chemical Structure : URB937

CAS No.: 1357160-72-5

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URB937 (URB 937)

货号: PC-38094Not For Human Use, Lab Use Only.

URB937 (URB 937) is a potent, peripherally restricted FAAH inhibitor with IC50 of 26.8 nM.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
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生物&药学活性

URB937 (URB 937) is a potent, peripherally restricted FAAH inhibitor with IC50 of 26.8 nM.
URB937 suppresses FAAH activity and increases anandamide levels outside the central nervous system (CNS), shows inability to access brain and spinal cord.
URB937 attenuates behavioral responses indicative of persistent pain in rodent models of peripheral nerve injury and inflammation, and prevents noxious stimulus-evoked neuronal activation in spinal cord regions implicated in nociceptive processing.
URB937 inhibits peripheral FAAH activity in vivo both rapidly and lastingly.
URB937 attenuates formalin-induced pain behavior and spinal cord Fos protein expression in rats.

物理化学性质&存储条件

分子量	354.406
分子式	C20H22N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3'-Carbamoyl-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate

参考文献

1. Clapper JR, et al. Nat Neurosci. 2010 Oct;13(10):1265-70.

2. Moreno-Sanz G, et al. Pharmacol Res. 2011 Oct;64(4):359-63.

3. Moreno-Sanz G, et al. Pharmacol Res. 2014 Sep;87:87-93.

4. Sasso O, et al. Pharmacol Res. 2012 May;65(5):553-63.

URB937 (URB 937)

生物&药学活性

物理化学性质&存储条件

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URB937 (URB 937)

生物&药学活性

物理化学性质&存储条件

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