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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Monoacylglycerol Lipase (MAGL)-URB602
URB602

Chemical Structure : URB602

CAS No.: 565460-15-3

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URB602 (URB 602, URB-602)

货号: PC-42260Not For Human Use, Lab Use Only.

URB602 is a selective, noncompetitive monoacylglycerol lipase (MAGL) inhibitor with IC50 of 28 uM against rat brain MAGL.

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25 mg ￥880 In stock
50 mg ￥1280 In stock
100 mg ￥1980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

URB602 is a selective, noncompetitive monoacylglycerol lipase (MAGL) inhibitor with IC50 of 28 uM against rat brain MAGL.
URB602 elevates 2-AG levels and enhances 2-AG-mediated signaling in neurons, prolongs endocannabinoid-mediated changes in synaptic strength in acutely dissected rat hippocampal slices.
URB602 showed anti-inflammatory and anti-nociceptive effect in murine model of acute inflammation.

物理化学性质&存储条件

分子量 295.3755
分子式 C19H21NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

Carbamic acid, N-[1,1'-biphenyl]-3-yl-, cyclohexyl ester

参考文献

1. Hohmann AG, et al. Nature. 2005 Jun 23;435(7045):1108-12.

2. King AR, et al. Chem Biol. 2007 Dec;14(12):1357-65.

3. Makara JK, et al. Nat Neurosci. 2005 Sep;8(9):1139-41.

4. Comelli F, et al. Br J Pharmacol. 2007 Nov;152(5):787-94.

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