UR778Br | IQGAP1 inhibitor | Probechem Biochemicals

Chemical Structure : UR778Br

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UR778Br (UR 778Br)

货号: PC-22489Not For Human Use, Lab Use Only.

UR778Br is a potent small molecule inhibitor of scaffolding protein IQGAP1, taregting the IQGAP1-GRD domain, selectively inhibits growth of human acute myeloid leukemia.

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生物&药学活性

UR778Br is a potent small molecule inhibitor of scaffolding protein IQGAP1, taregting the IQGAP1-GRD domain, selectively inhibits growth of human acute myeloid leukemia.
UR778Br reduces proliferation, causes G2M cell cycle arrest, induces apoptosis and suppresses colony forming potential in leukemia cell lines.
UR778Br dose-dependently decreases viability, causs apoptosis and decreases colony formation potential in primary AML cells while sparing normal bone marrow cells.
IQGAP1 is a multi-domain, cytoskeletal protein, shown to be upregulated in many solid tumors.

物理化学性质&存储条件

分子量	418.29
分子式	C20H20BrNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-bromo-1-butyl-3-hydroxy-3-(2-(2-hydroxyphenyl)-2-oxoethyl)indolin-2-one

参考文献

1. Sahasrabudhe DM, et al. Sci Rep. 2024 Jun 4;14(1):12868.

UR778Br (UR 778Br)

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UR778Br (UR 778Br)

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