UR214-9

Chemical Structure : UR214-9

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货号: PC-27131Not For Human Use, Lab Use Only.

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200 mg		Get quote

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生物&药学活性

UR214-9 is a forchlorfenuron (FCF) analog and inhibitor of septin oligomeric assembly via preventing incorporation of SEPT2/7/9, into canonical hetero-octamers, decreases viability and proliferation in both ovarian and endometrial cancer cell lines, selectively suppress HER2 expression.
UR214-9 decreases the expression of human epididymis protein 4 (HE4) in ECC-1 and HCH-1 cells.
UR214-9 (33 uM) selectively inhibits HER2 expression in both ECC-1 and HCH-1 cells, but not EGFR also suppress HER2 expression.
UR214-9 disrupts the incorporation of SEPT2, SEPT7, and SEPT9 into canonical septin hetero-octamers. causes defects in cytokinesis, altered cell migration, viability, and remodels septin-actin architectures, ultimately impairing tumor cell growth.

物理化学性质&存储条件

分子量	368.11
分子式	C13H7Cl2F4N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2,6-dichloropyridin-4-yl)-3-(2-fluoro-3-(trifluoromethyl)phenyl)urea

参考文献

1. Kim KK, et al. Sci Rep. 2020 Feb 24;10(1):3241.

2. Khazan N, et al. bioRxiv [Preprint]. 2026 Jun 9:2026.06.09.731048.

UR214-9

生物&药学活性

物理化学性质&存储条件

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UR214-9

生物&药学活性

物理化学性质&存储条件

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