UR-1102 |CAS:1198153-15-9 Probechem Biochemicals

Chemical Structure : UR-1102

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UR-1102 (UR 1102;UR1102;Epaminurad)

货号: PC-60708Not For Human Use, Lab Use Only.

UR-1102 is a novel potent and selective, orally active URAT1 inhibitor with Ki of 57 nM, 130 and 42-fold selectivity over OAT1 and OAT3, respectively.

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生物&药学活性

UR-1102 is a novel potent and selective, orally active URAT1 inhibitor with Ki of 57 nM, 130 and 42-fold selectivity over OAT1 and OAT3, respectively.
UR-1102 increases the fractional excretion of urinary uric acid, and reduces plasma uric acid more effectively in vivo, compared with benzbromarone.
UR-1102 also shows lower in vitro potential for mechanisms causing the hepatotoxicity induced by benzbromarone.

物理化学性质&存储条件

分子量	414.053
分子式	C14H10Br2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3,5-dibromo-4-hydroxyphenyl)(2,3-dihydro-4H-pyrido[4,3-b][1,4]oxazin-4-yl)methanone

参考文献

1. Ahn SO, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):157-66.

UR-1102 (UR 1102;UR1102;Epaminurad)

生物&药学活性

物理化学性质&存储条件

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UR-1102 (UR 1102;UR1102;Epaminurad)

生物&药学活性

物理化学性质&存储条件

参考文献

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