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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-p97/VCP-UPCDC-30766
UPCDC-30766

Chemical Structure : UPCDC-30766

CAS No.: 2152623-68-0

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UPCDC-30766 (UPCDC 30766)

货号: PC-20932Not For Human Use, Lab Use Only.

UPCDC-30766 (UPCDC 30766) is a potent, allosteric inhibitor of AAA+ ATPase p97 (valosin-containing protein, VCP) with biochemical IC50 of 12 nM, EC50 of 226 nM in cellular UbG76V-GFP accumulation assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

UPCDC-30766 (UPCDC 30766) is a potent, allosteric inhibitor of AAA+ ATPase p97 (valosin-containing protein, VCP) with biochemical IC50 of 12 nM, EC50 of 226 nM in cellular UbG76V-GFP accumulation assays.
UPCDC-30766 exhibits antiproliferative effect in the HCT116 cell line with IC50 of 340 nM.
UPCDC-30766 shows dose-dependent increases in Ub-K48 levels starting at 40 nM in PD assays, increases in CHOP and cleaved caspase-3 protein levels at 1 uM in colon cancer cell line HCT116.

物理化学性质&存储条件

分子量 594.68
分子式 C30H32F2N6O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(OCC#CC1=CC(F)=C(OCC2=NN=C(S[C@H]3C=CCCC3)N2C4=CC=CN=C4)C=C1F)NC5CCN(C)CC5

参考文献

1. LaPorte MG, et al. ACS Med Chem Lett. 2023 Jun 21;14(7):977-985.

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